pykd

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import pykd
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GENERIC_READ = 0x80000000
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GENERIC_WRITE = 0x40000000
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NULL = 0
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CREATE_ALWAYS = 2
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FILE_ATTRIBUTE_NORMAL  = 0x80
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def main():
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    kernel32 = pykd.module("kernel32")
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    HANDLE = pykd.typeInfo("Void*")
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    LPCWSTR = pykd.typeInfo("WChar*")
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    DWORD = pykd.typeInfo("UInt4B")
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    LPSECURITY_ATTRIBUTES = pykd.typeInfo("Void*")
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    CreateFileW_Type = pykd.defineFunction(HANDLE, pykd.callingConvention.NearStd)
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    CreateFileW_Type.append("lpFileName", LPCWSTR )
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    CreateFileW_Type.append("dwDesiredAccess", DWORD )
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    CreateFileW_Type.append("dwShareMode", DWORD )
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    CreateFileW_Type.append("lpSecurityAttributes", LPSECURITY_ATTRIBUTES )
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    CreateFileW_Type.append("dwCreationDisposition", DWORD )
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    CreateFileW_Type.append("dwFlagsAndAttributes", DWORD )
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    CreateFileW_Type.append("hTemplateFile", HANDLE )
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    CreateFileW = pykd.typedVar( CreateFileW_Type, kernel32.CreateFileW )
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    fileHandle = CreateFileW( 
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        "C:\\temp\\testfile.txt",
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        GENERIC_READ | GENERIC_WRITE,
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        0,
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        NULL,
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        CREATE_ALWAYS,
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        FILE_ATTRIBUTE_NORMAL,
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        NULL )
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    print "File Handle", hex(fileHandle)
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if __name__ == "__main__":
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    main()
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